L858r意思

"L858R" is a specific mutation in the gene called EGFR (Epidermal Growth Factor Receptor). This mutation is found in some non-small cell lung cancers and is associated with sensitivity to certain tyrosine kinase inhibitor (TKI) drugs used in cancer treatment, such as gefitinib and erlotinib.

The "L858R" mutation refers to a substitution of an arginine (R) for a leucine (L) at position 858 in the EGFR protein. This mutation leads to an overactive EGFR, which can cause uncontrolled cell growth and contribute to the development of cancer.

Detection of the L858R mutation in cancer patients can guide treatment decisions, as patients with this mutation may be more likely to respond to targeted therapies that inhibit the activity of the mutated EGFR protein. However, the effectiveness of these treatments can vary, and not all patients with the L858R mutation will experience the same benefits.